- Title
- IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis
- Creator
- Malhotra, S.; Morcillo-Suárez, C.; Chan, A.; Vandenbroeck, K.; Navarro, A.; Bustamante, M. F.; Rio, J.; Akkad, D. A.; Giacalone, G.; Sánchez, A. J.; Leyva, L.; Alvarez-Lafuente, R.; Brassat, D.; Zettl, U. K.; Oksenberg, J.; Montalban, X.; Comabella, M.; Goertsches, R.; Lechner-Scott, J.; Urcelay, E.; Fernández, O.; Drulovic, J.; García-Merino, A.; Boneschi, F. Martinelli
- Relation
- Journal of Neuroimmunology Vol. 239, Issue 1-2, p. 101-104
- Publisher Link
- http://dx.doi.org/10.1016/j.jneuroim.2011.08.004
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2011
- Description
- Recent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n=281) and non-responders (n=307) to IFNβ. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFNβ in MS patients.
- Subject
- multiple sclerosis; polymorphisms; interferon-beta; response
- Identifier
- http://hdl.handle.net/1959.13/937068
- Identifier
- uon:12486
- Identifier
- ISSN:0165-5728
- Language
- eng
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